In 1992, Trend Micro took over a Japanese software firm to form Trend Micro Devices and established headquarters in Japan. Shortly after establishing the company, its founders moved headquarters to Taipei.
The company was established with proceeds from Steve Chang's previous sale of a copy protection dongle to a United States-based Rainbow Technologies. The company was founded in 1988 in Los Angeles by Steve Chang, his wife, Jenny Chang, and her sister, Eva Chen (陳怡樺).